News
Lotte gets her PhD!!!
Much delayed by COVID, but Lotte was finally allowed to defend her thesis. Opponents and guests were virtually present, while Lotte filled the empty room with great display of her expertise and knowledge!
Much delayed by COVID, but Lotte was finally allowed to defend her thesis. Opponents and guests were virtually present, while Lotte filled the empty room with great display of her expertise and knowledge!
Yes, he is different! We welcome the first MD in our group! Maarten will carry out a phase1/2 trial to test a new therapy against KRAS mutant colon cancer. In parallel he will test organoids as companion diagnostics. Maarten will be co-supervised by Jeanine Roodhart, medical oncologist in our hospital.
COVID lockdown provided a window to reexamine current literature regarding stem cell function and environmental control. Joris took the lead and shaped his long-term interest into a new review.
Lotte publishes experimental data in Cell reports that the number of functional stem cells increases in intestinal crypts upon caloric restriction, confirming prior studies using marker gene expression.
Most of our lab work has been restricted since half of March. After about two months, we are enthusiastic to slowly reopening the labs. Virtual meetings are likely to stay in some sort…
Thankful for our great and long-lasting collaboration with the Van Rheenen laboratory! New work, spearheaded by the Van Rheenen lab, in Cell Stem Cell about the origin of liver metastases from colorectal cancers. Using genetic mouse models and intravital imaging, it turns out that the major suspects, i.e. so-called cancer Read more…
Hugo is a member of a multidisciplinary research team (AMOLF, NKI, Hubrecht & UMCU) that successfully applied for a NWO groot research grant (~€2,5M). The team will perform functional studies on rare cell types in the gut to delineate their relationship with common diseases like Crohn’s, obesity, infections or irritable Read more…
We wrote a review about the types of oncogenic mutations in the MAPK pathway in colorectal cancer. They are similar but different. Unfortunately, studying them is often comparing apples to oranges. Organoid models and CRISPR genome editing might pave the way…
Michiel was awarded a prestigious Marie Curie research grant to continue his science in our lab after an earlier successful period at MSKCC in NY, USA. Well done! Michiel will study genetic alterations in esophageal adenocarcinoma using patient organoids and high-end imaging.
Jasmin successfully defended her thesis called ‘Similar but different: Oncogenic MAPK pathway mutations in colorectal cancer’. Jasmin is fully prepared to take on the business world. We wish her all the luck in her career and life.