Although the research fields of cell biology and genetics are well-established, there is relatively little interaction between both disciplines. Most notably, direct integration between live-cell microscopy with single cell genetics has been challenging to establish. To that end, we are now exploring new strategies, like microfluidics, to combine our established live-cell imaging of tumor organoid growth with single cell genomic analysis. We are interested to decipher the direct genetic consequences of abnormal cellular processes in tumor cells, as well as to study tumor evolution with cell cycle resolution.