Super happy with this technology, foremost as we now can make (complex) knock-ins in human organoids on weekly basis. Major advantages are no off-targets. As a consequence, you can pool all knock-in cells to expedite culture expansion and/or maintenance of polyclonality (in case of tumors). Targeting vectors enable one-step cloning (and all are available @Addgene).
Overall result, amazing looking knock-in organoids within 2wks! @PLOS BIOLOGY
Hugo received new funding from KWF (€820k), the Dutch Cancer Foundation, to strengthen our team with two new PhD students. We will use this support to make a deep dive into the tumor microenvironment of Read more…
Hugo received a prestigious ERC consolidator grant (€2,0M) from the EU in support of our studies to understand the evolution of the tumor genome during the earliest formation of colon cancer. The project will rely Read more…
Beautiful ceremony in the Amsterdam Stedelijk Museum for modern art. AMMODO Science Award is a biannual prize for early-career scientists to continue their research line as they seem fit (€350k). Proud to be listed among Read more…