Integrated multi-omics analyses of organoid model
systems to study lineage specification in the intestinal epithelium (Mol Syst
Biol). Great work, spearheaded by the lab of Michiel Vermeulen, RIMLS,
Nijmegen.
Ever wondered what the cellular trajectory is of a cancer cell metastasizing to the liver? Maria finished a tour de force @Cancer Research, mapping shapeshifting cancer stem cell phenotypes with high precision during metastasis formation. Read more…
Super happy with this technology, foremost as we now can make (complex) knock-ins in human organoids on weekly basis. Major advantages are no off-targets. As a consequence, you can pool all knock-in cells to expedite Read more…
Proud on this fantastic publication in Nat Genet. We established 3D Live-Seq: the integration of live-cell imaging of tumor organoids and whole-genome sequencing of each imaged cell. Combined, these super powerful technologies enable the exact Read more…
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