We developed and validated a synthetic enhancer/promoter element that provides specific transcriptional activity in intestinal stem cells. The reporter, called STAR, is a user-friendly system to monitor and manipulate stem cells in human organoids. Among others, we documented that cell fate plasticity in tumors is an inherited trait from normal cells, rather than acquired by specific cancer mutations.
Much delayed by COVID, but Lotte was finally allowed to defend her thesis. Opponents and guests were virtually present, while Lotte filled the empty room with great display of her expertise and knowledge!