Hugo received new funding from KWF (€820k), the Dutch Cancer Foundation, to strengthen our team with two new PhD students. We will use this support to make a deep dive into the tumor microenvironment of invasive fronts at the earliest stages of colorectal cancer formation.
Hugo received a prestigious ERC consolidator grant (€2,0M) from the EU in support of our studies to understand the evolution of the tumor genome during the earliest formation of colon cancer. The project will rely heavily on genome analysis at the single-cell level in both tumors and multi-regional organoid derivatives Read more…
Beautiful ceremony in the Amsterdam Stedelijk Museum for modern art. AMMODO Science Award is a biannual prize for early-career scientists to continue their research line as they seem fit (€350k). Proud to be listed among all previous recipients. Thankful to all current and past team members, and colleagues in the Read more…
Drug-resistant cells are often metabolically inactive, compromising the suitability of mostly used drug response assays on organoids. In this publication @Cell reports, we designed a novel microscopy-based drug screen that accurately distinguishes dead from alive organoids. We found microtubule-targeting agents, commonly used in clinical oncology, to eliminate RAS mutant cells Read more…
Excited that Oncode Institute will continue to support fundamental research in our fight against cancer. Needless to say, we are proud to remain a member (senior now) and ready to roar!
Maria Heinz successfully defended her thesis called ‘Cellular heterogeneity during metastatic colonization of colorectal cancer’. Her thesis was a tour de force at a complex topic, but she excellent and showed great expertise of the topic and science in general. Both her social coffee glue and intellect will be missed. Read more…
Yannik successfully defended his thesis called ‘Karyotype diversification in colorectal cancer’. His PhD trajectory was co-supervised by Prof. dr. Leon Terstappen of the University of Twente. Yannik will continue to pursue his interest in CRISPR editing of patient models within the infrastructure of Roche Institute for Translational Bioengineering (Basel, Switzerland). Read more…
Ever wondered what the cellular trajectory is of a cancer cell metastasizing to the liver? Maria finished a tour de force @Cancer Research, mapping shapeshifting cancer stem cell phenotypes with high precision during metastasis formation. Ooh…, regarding epithelial self-organization in organoids: it is conserved between mice, human, normal and cancer Read more…
Super happy with this technology, foremost as we now can make (complex) knock-ins in human organoids on weekly basis. Major advantages are no off-targets. As a consequence, you can pool all knock-in cells to expedite culture expansion and/or maintenance of polyclonality (in case of tumors). Targeting vectors enable one-step cloning Read more…
Proud on this fantastic publication in Nat Genet. We established 3D Live-Seq: the integration of live-cell imaging of tumor organoids and whole-genome sequencing of each imaged cell. Combined, these super powerful technologies enable the exact reconstruction how evolving tumor genomes change and mutate over consecutive cell generations. Mapping the tempo Read more…